Dr. Wyatt is a clinical psychologist, sex therapist and professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA. She was the first person of color to receive an NIMH Research Scientist Career Development Awardee for 17 years. She has conducted national and international research since 1980, funded by the National Institutes of Mental Health, the National Institute of Drug Abuse, state and private foundations.

Dr. Wyatt is Director of the UCLA Sexual Health Program, an Associate Director of the UCLA AIDS Institute and coordinates a core of behavioral scientists who consult with other researchers to recruit underserved populations and conduct research that effectively incorporates socio-cultural factors into HIV/AIDS research. The program also provides workshops on mentoring and investigation to conduct research and find success in academic settings. Dr. Wyatt has received numerous awards and honors for her scientific accomplishments, mentoring, and teaching. She has also testified before the United States Congress ten times on issues related to women's health and overall health policy. She was the first African-American woman to be licensed as a psychologist in the state of California.